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early-onset Alzheimer's disease
Etiology:
1) familial Alzheimer's disease
2) Down syndrome
Clinical manifestations:
- 38% of cases may present without memory impairment
- may present with behavioral, executive function, visuospatial, or language problems [1]
Laboratory:
- see Alzheimers' disease
- also see ARUP consult [3]
Radiology:
- see Alzheimer's disease
Note:
- neuroimaging takes precedence over lumbar puncture or genetic testing [2]
Interactions
disease interactions
Related
familial Alzheimer's disease (FAD)
General
Alzheimer's disease (AD)
Properties
PATHOLOGY: neurofibrillary tangle
amyloid plaque
cerebral amyloid angiopathy
granulovacuolar change
Hirano body
References
- Balasa M et al
Clinical features and APOE genotype of pathologically proven
early-onset Alzheimer disease
Neurology May 17, 2011 76:1720-1725
PMID: 21576687
http://www.neurology.org/content/76/20/1720.abstract
- N Engl J Med Knowledge+
Question of the Week. March 17, 2015
- Mayeux R.
Clinical practice. Early Alzheimer's disease.
N Engl J Med 2010 Jun 19; 362:2194.
PMID: 20558370
- Knopman DS et al.
Practice parameter: diagnosis of dementia (an evidence-based
review). Report of the Quality Standards Subcommittee of the
American Academy of Neurology.
Neurology 2001 May 9; 56:1143
PMID: 11342678
- ARUP Consult:
Early-Onset Alzheimer's Panel, Sequencing
https://arupconsult.com/ati/early-onset-alzheimers-panel-sequencing